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quinupristin/dalfopristin boosts amounts of erythromycin lactobionate by lowering metabolism. Contraindicated. Risk of prolonged QTc interval.quinupristin/dalfopristin will improve the amount or effect of acalabrutinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Closely. Decrease acalabrutinib dose to 10